PPAR-αLigands as Potential Therapeutic Agents for Wet Age-Related Macular Degeneration
نویسندگان
چکیده
منابع مشابه
PPAR-α Ligands as Potential Therapeutic Agents for Wet Age-Related Macular Degeneration
The peroxisome proliferator-activated receptors (PPAR's) are members of the steroid/thyroid nuclear receptor, superfamily of transcription factors. There are currently three known PPAR subtypes, alpha, beta, and gamma. The PPARs are now recognized participants in a number of biological pathways some of which are implicated in the pathogenesis of age-related macular degeneration (AMD). These inc...
متن کاملWet Age Related Macular Degeneration
Age related macular degeneration (AMD) is the leading cause of blindness in the developed countries. Approximately 8 million people in America have AMD and the number of advanced AMD is likely to rise by 50% by year 2020 due to the projected increase in the number of elderly people (Friedman et al., 2004). AMD is a condition of significant morbidity in terms of both physical and mental health (...
متن کاملImaging of Wet Age-Related Macular Degeneration
All images are acquired on a Spectralis device from Heidelberg Engineering. Image courtesy of Dr. (med) Ke-nan Damer, Birmingham Midlands Eye Centre, Sandwell and West Birmingham NHS Trust. Fig. 1. a Shows the macula of a left eye with reduced foveal reflectivity on the infra-red picture, which is due to intra-retinal fluid caused by choroidal neovascularization (CNV) related to wet AMD. In b ,...
متن کاملBevasiranib for the Treatment of Wet, Age-Related Macular Degeneration
Age- related Macular Degeneration (AMD) is the leading cause of severe visual impairment in people 65 years and older in industrialized nations. Exudative, or "wet", AMD is a late form of AMD (as distinguished from atrophic, so-called dry, AMD) and is responsible for over 60% of all cases of blindness due to AMD. It is widely accepted that vascular endothelial growth factor (VEGF) is a key comp...
متن کاملCost effectiveness of treatments for wet age-related macular degeneration.
Age-related macular degeneration (AMD) is a leading cause of blindness in people aged ≥50 years. Wet AMD in particular has a major impact on patient quality of life and imposes substantial burdens on healthcare systems. This systematic review examined the cost-effectiveness data for current therapeutic options for wet AMD. PubMed and EMBASE databases were searched for all articles reporting ori...
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ژورنال
عنوان ژورنال: PPAR Research
سال: 2008
ISSN: 1687-4757,1687-4765
DOI: 10.1155/2008/821592